Key result
Trypanosoma cruzi DNA was amplified in 18 of 21 (85.7%) heart samples from seropositive patients with severe chronic chagasic cardiomyopathy, compared to 0% in patients without severe disease or seronegative controls.
Why the study?
Is Trypanosoma cruzi DNA present in the inflammatory lesions of chronic cardiac Chagas' disease?
Population
20 autopsy specimens from patients
Comparison
Polymerase chain reaction using T… vs Seronegative patients and seropositive patients…
Design
Cross-sectional
Authors
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Supports persistent T. cruzi in severe chagasic cardiomyopathy lesions; hypothesis-generating for antiparasitic trials.
Observational (n=20)
No
Is Trypanosoma cruzi DNA present in the inflammatory lesions of chronic cardiac Chagas' disease?
Absolute Event Rate: 85.7% vs 0%
Trypanosoma cruzi DNA is present in the inflammatory lesions of chronic cardiac Chagas' disease, suggesting that persistent organisms or their genomic fragments may play a role in chronic myocardial injury.
Jones et al. (1993) conducted an observational in Chronic chagasic cardiomyopathy (n=20). Severe chronic chagasic cardiomyopathy (T. cruzi seropositivity) vs. Seronegative patients and seropositive patients without severe cardiomyopathy was evaluated on Amplification of T. cruzi DNA sequences from heart samples. Trypanosoma cruzi DNA was amplified in 18 of 21 (85.7%) heart samples from seropositive patients with severe chronic chagasic cardiomyopathy, compared to 0% in patients without severe disease or seronegative controls.
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