Key result
Myocardial parasite persistence of T. cruzi DNA was significantly associated with high-grade myocarditis (P=0.014), but not with patient survival time.
Why the study?
Is parasite persistence in endomyocardial biopsies associated with high-grade myocarditis and survival in patients with chronic chagasic cardiopathy?
Population
29 outpatients with chronic chagasic cardiopathy, mean age 43 (SD 9) years, 25 males and 4 females.
Comparison
Evaluation of parasite persistence in… vs Absence of parasite persistence
Design
Cohort
Follow-up
median 369 days (range 3-2861 days)
Authors
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Parasite persistence may flag high-grade myocarditis risk in chronic Chagas cardiomyopathy; leaves open survival impact and therapeutic implications.
Observational (n=29)
Is parasite persistence in endomyocardial biopsies associated with high-grade myocarditis and survival in patients with chronic chagasic cardiopathy?
p-value: p=0.014
In patients with chronic chagasic cardiopathy, the persistence of Trypanosoma cruzi DNA in the myocardium is associated with high-grade myocarditis, though it does not appear to significantly impact survival time.
Benvenuti et al. (2008) conducted an observational in chronic chagasic cardiopathy (n=29). Myocardial parasite persistence (T. cruzi DNA) vs. No parasite persistence was evaluated on High-grade myocarditis (p=0.014). Myocardial parasite persistence of T. cruzi DNA was significantly associated with high-grade myocarditis (P=0.014), but not with patient survival time.
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