Key result
Analysis of heart tissue from 3 patients with chronic Chagas' heart disease detected widely dispersed but low amounts of T. cruzi DNA, excluding heart tissue as a major parasite reservoir.
Population
3 patients with chronic Chagas' heart disease
Design
Case_series
Authors
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Heart tissue unlikely major T. cruzi reservoir in chronic Chagas; hypothesis-generating for drivers of persistent myocarditis.
Case Report (n=3)
The study demonstrates that while T. cruzi DNA remnants are present in the heart tissue of patients with chronic Chagas' heart disease, intact parasites are rare, suggesting the heart is not a major parasite reservoir.
Elias et al. (2003) conducted a case report in Chronic Chagas' heart disease (n=3). Tissue analysis for Trypanosoma cruzi was evaluated on Presence of Trypanosoma cruzi in heart tissue. Analysis of heart tissue from 3 patients with chronic Chagas' heart disease detected widely dispersed but low amounts of T. cruzi DNA, excluding heart tissue as a major parasite reservoir.
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