Population
Argentinean patients with end-stage chronic Chagas heart disease (cardiac lesions from necropsies or explants)
Design
Cross-sectional
Authors
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Supports persistent T. cruzi in Chagas lesion severity; hypothesis-generating for targeted therapy before practice change.
The persistence of Trypanosoma cruzi DNA in cardiac lesions is strongly associated with the severity of inflammation, fibrosis, and clinical progression in chronic Chagas heart disease.
Schijman et al. (2004) studied this question.