Key result
This review discusses the contribution of recurrent venous thrombosis and inherited thrombophilia to the pathogenesis and risk of developing post-thrombotic syndrome after deep vein thrombosis.
This review highlights the importance of understanding the pathophysiology and risk factors, such as recurrent venous thrombosis and inherited thrombophilia, to prevent post-thrombotic syndrome.
May refine post-DVT risk assessment; leaves open whether targeting these factors reduces incidence.
Post-thrombotic syndrome is an important chronic complication of deep vein thrombosis. This syndrome can be debilitating to patients and has a major economic impact on health care services. The pathophysiology of post-thrombotic syndrome is currently incompletely understood. Because therapeutic options for post-thrombotic syndrome are extremely limited and results are often disappointing, recognizing of the pathophysiology and risk factors of this syndrome is essential to prevent the disabling consequences of this disease. The present paper focuses on risk determinants of post-thrombotic syndrome after deep vein thrombosis. The contribution of recurrent venous thrombosis and inherited thrombophilia to the pathogenesis of this syndrome is reviewed and discussed in details.
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Raghid Kreidy (2011) conducted a review in Post-thrombotic syndrome after deep vein thrombosis. Recurrent venous thrombosis and inherited thrombophilia was evaluated on Pathogenesis of post-thrombotic syndrome. This review discusses the contribution of recurrent venous thrombosis and inherited thrombophilia to the pathogenesis and risk of developing post-thrombotic syndrome after deep vein thrombosis.
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