Key result
Postthrombotic syndrome is linked to a ~10-fold higher rate of recurrent venous thrombosis.
Why the study?
The role of recurrent venous thrombosis and inherited thrombophilia in the pathogenesis of postthrombotic syndrome was not well defined.
Do recurrent venous thrombosis and inherited thrombophilia increase the incidence and severity of postthrombotic syndrome in patients with lower extremity venous thrombosis?
Observational (n=206)
Do recurrent venous thrombosis and inherited thrombophilia increase the incidence and severity of postthrombotic syndrome in patients with lower extremity venous thrombosis?
Absolute Event Rate: 33.3% vs 3.4%
p-value: p=<.001
Recurrent venous thrombosis and inherited thrombophilia are significantly associated with an increased incidence and severity of postthrombotic syndrome following lower extremity venous thrombosis.
Postthrombotic syndrome marks higher recurrent thrombosis risk; leaves open whether intensified surveillance or therapy modifies outcomes.
Postthrombotic syndrome (PTS) is a common complication of deep vein thrombosis. This study aims to assess the role of recurrent venous thrombosis and inherited thrombophilia in the pathogenesis of PTS. A series of 206 patients diagnosed with lower extremity venous thrombosis were retrospectively reviewed. The PTS was observed in 30.58% of the patients. Recurrent venous thrombosis was identified in 3.4% of the patients without PTS and in 33.3% of patients with PTS (P < .001). Inherited thrombophilia alone or in association with recurrent venous thrombosis was more commonly detected when PTS was moderate to severe (P = .04 and <.001) or severe (P < .001). Recurrent venous thrombosis increases the incidence of PTS significantly. The severity of PTS raises when an underlying thrombophilia is present either alone or in association with recurrent venous thrombosis.
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Raghid Kreidy (2013) conducted an observational in Lower extremity venous thrombosis (n=206). Recurrent venous thrombosis and inherited thrombophilia vs. No recurrent venous thrombosis or inherited thrombophilia was evaluated on Recurrent venous thrombosis in patients with vs without postthrombotic syndrome (PTS) (p=<.001). Recurrent venous thrombosis was identified in 33.3% of patients with postthrombotic syndrome compared to 3.4% of patients without the syndrome (P<.001).
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