Key result
Every 10 mmHg increase in systolic blood pressure increased the risk of ischemic stroke by 36% and hemorrhagic stroke by 69%, while diabetes increased risks by 170% and 147%, respectively.
Why the study?
Do raised systolic blood pressure, diabetes, and smoking increase the risk of ischemic and hemorrhagic stroke in women in the Asia-Pacific region?
Cohort (n=214,032)
Yes
Do raised systolic blood pressure, diabetes, and smoking increase the risk of ischemic and hemorrhagic stroke in women in the Asia-Pacific region?
Effect estimate: 36% increase in IS and 69% increase in HS per 10 mmHg SBP
Raised systolic blood pressure, diabetes, and smoking are major modifiable risk factors for both ischemic and hemorrhagic stroke among women in the Asia-Pacific region.
May support risk assessment in Asian women; extends observational stroke data but leaves causal effects and practice change open.
National data from the Asia-Pacific region suggest that stroke accounts for over 10% of female deaths. With general aging in the region, and longer life expectancies for women than men, action is required to maintain recent improvements in female death rates from stroke. However, local data on incidence and risk factors for stroke amongst women are scarce. Data from 214,032 women in the Asia Pacific Cohort Studies Collaboration were thus used to investigate the risk factors for stroke in the region. Raised systolic blood pressure and diabetes were found to be key risk factors for both ischemic (IS) and hemorrhagic (HS) stroke. After adjustment for other risk factors, every extra 10 mmHg systolic blood pressure increased risk of IS by 36% and HS by 69%, whilst diabetes increased risk of IS by 170% and HS by 147%. Smoking was also an important risk factor for IS and HS; risk was reduced by quitting.
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Woodward et al. (2011) conducted a cohort in Stroke (n=214,032). Raised systolic blood pressure and diabetes was evaluated on Ischemic and hemorrhagic stroke (36% increase in IS and 69% increase in HS per 10 mmHg SBP). Every 10 mmHg increase in systolic blood pressure increased the risk of ischemic stroke by 36% and hemorrhagic stroke by 69%, while diabetes increased risks by 170% and 147%, respectively.
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