Key result
The Arg16Gli genotype was associated with a 4.83-fold increased hazard of arterial hypotension (95% CI 1.13-20.50; p=0.033) and higher ephedrine requirements compared to the Arg16Arg genotype.
Why the study?
Does the Arg16Gli polymorphism of the beta-2 adrenergic receptor gene influence the incidence of arterial hypotension and ephedrine use in healthy parturients submitted to subarachnoid anesthesia for Cesarean section?
Population
Healthy parturients (ASA I and II) submitted to subarachnoid anesthesia for elective Cesarean section (n = 50)
Comparison
Arg16Gli and Gli16Gli genotypes of the beta-2… vs Arg16Arg genotype
Design
Cohort
Authors
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Arg16Gli may flag higher hypotension risk in cesarean spinal anesthesia; hypothesis-generating, requires prospective validation before any practice change.
Observational (n=50)
Does the Arg16Gli polymorphism of the beta-2 adrenergic receptor gene influence the incidence of arterial hypotension and ephedrine use in healthy parturients submitted to subarachnoid anesthesia for Cesarean section?
Hazard Ratio: 4.83 (95% CI 1.13–20.5)
p-value: p=0.033
The Arg16Arg genotype of the beta-2 adrenergic receptor confers better blood pressure stability and requires less ephedrine in parturients undergoing subarachnoid anesthesia for Cesarean section.
Magalhães et al. (2010) conducted an observational in Pregnancy requiring elective Cesarean section under subarachnoid anesthesia (n=50). Arg16Gli genotype vs. Arg16Arg genotype was evaluated on Incidence of arterial hypotension (HR 4.83, 95% CI 1.13-20.50, p=0.033). The Arg16Gli genotype was associated with a 4.83-fold increased hazard of arterial hypotension (95% CI 1.13-20.50; p=0.033) and higher ephedrine requirements compared to the Arg16Arg genotype.
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