Key result
A high-fat meal significantly reduced forearm vascular conductance responses to mental stress from 1.5 to 0.8 units, an impairment primarily observed in individuals homozygous for the Glu27 allele.
Why the study?
Does a high-fat meal reduce muscle vasodilatation response to mental stress in healthy individuals with different beta2-adrenoceptor polymorphisms?
Does a high-fat meal reduce muscle vasodilatation response to mental stress in healthy individuals with different beta2-adrenoceptor polymorphisms?
Absolute Event Rate: 0.8% vs 1.5%
p-value: p=0.04
A high-fat meal acutely impairs endothelial-mediated muscle vasodilatation during mental stress, particularly in individuals with the Glu27 allele of the beta2-adrenoceptor gene who otherwise exhibit augmented vascular responsiveness.
Should not yet alter dietary advice; leaves open whether beta2-adrenoceptor genotype modifies acute postprandial vascular responses.
BACKGROUND: Forearm blood flow responses during mental stress are greater in individuals homozygous for the Glu27 allele. A high-fat meal is associated with impaired endothelium-dependent dilatation. We investigated the impact of high-fat ingestion on the muscle vasodilatory responses during mental stress in individuals with the Glu27 allele and those with the Gln27 allele of the beta2-adrenoceptor gene. METHODS: A total of 162 preselected individuals were genotyped for the Glu27Gln beta2-adrenoceptor polymorphism. Twenty-four individuals participated in the study. Fourteen were homozygous for the Gln27 allele (Gln27Gln, 40 +/- 2 years; 64 +/- 2 kg), and 10 were homozygous for the Glu27 allele (Glu27Glu, 40 +/- 3 years; 65 +/- 3 kg). Forearm blood flow was evaluated by venous occlusion plethysmography before and after ingestion of 62 g of fat. RESULTS: The high-fat meal caused no changes in baseline forearm vascular conductance (FVC, 2.2 +/- 0.1 vs. 2.4 +/- 0.2; P = 0.27, respectively), but reduced FVC responses to mental stress (1.5 +/- 0.2 vs. 0.8 +/- 0.2 units; P = 0.04). When volunteers were divided according to their genotypes, baseline FVC was not different between groups (Glu27Glu = 2.4 +/- 0.1 vs. Gln27Gln = 2.1 +/- 0.1 units; P = 0.08), but it was significantly greater in Glu27Glu individuals during mental stress (1.9 +/- 0.4 vs. 1.0 +/- 0.3 units; P = 0.04). High-fat intake eliminated the difference in FVC responses between Glu27Glu and Gln27Gln individuals (FVC, 1.3 +/- 0.4 vs. 1.2 +/- 0.4; P = 0.66, respectively). CONCLUSION: These findings demonstrate that a high-fat meal impairs muscle vasodilatation responses to mental stress in humans. However, this reduction can be attributed to the presence of the homozygous Glu27 allele of the beta2-adrenoceptor gene.
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Gowdak et al. (2010) studied Healthy (n=24). High-fat meal vs. Baseline (before meal) was evaluated on Forearm vascular conductance (FVC) response to mental stress (p=0.04). A high-fat meal significantly reduced forearm vascular conductance responses to mental stress from 1.5 to 0.8 units, an impairment primarily observed in individuals homozygous for the Glu27 allele.
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