Mean Platelet Volume in Patients With Obstructive Sleep Apnea Syndrome and Concurrent Hypertension and Diabetes Mellitus

Objective: Obstructive Sleep Apnea syndrome (OSAS) is a common disorder affecting especially middle-aged adults. Elevated platelet activation and aggregation have a close relationship with cardiovascular complications. Mean platelet volume (MPV) is a marker of platelet activation. The influence of OSAS on platelet activation is not fully understood subject. Materials and Methods: One hundred ninety-two patients who were included in this study examined retrospectively with polysomnography. The Apnea-hypopnea index (AHI) above five was accepted as OSAS. The AHI under five was decided as control group. The OSAS group was categorized into three groups according to AHI values. Patients whose AHI was 5-15 decided as mild, 15-30 as moderate, and above 30 was severe group. The control group consist of 28 patients (14.6%), mild OSAS group consist of 31 patients (16.1%), moderate OSAS group consist of 42 patients (21.9%), and severe OSAS group consist of 91 patients (47.6%). The medical and sleep histories, demographic data, cardiovascular and metabolic histories, drug use of the patients were retrospectively examined. Laboratory analyze consisted of a routine blood evaluation. Hypertension and diabetes mellitus history also investigated. Results: There were significant differences between the groups in desaturation index, Body Mass index, AHI, minimum oxygen saturation, and arousal (p<0.001). There was no significant difference between the groups in terms of hemoglobin, leukocyte, platelet count, and MPV.