Key result
Percutaneous renal denervation decreased the low frequency component of heart rate variability from 4.964 to 1.853 and reduced blood pressure by 30/10 mmHg at 1 month in a patient with resistant hypertension.
Why the study?
Does catheter-based renal denervation reduce the low frequency component of heart rate variability in a patient with resistant hypertension?
Case Report (n=1)
No
Does catheter-based renal denervation reduce the low frequency component of heart rate variability in a patient with resistant hypertension?
A 5-minute heart rate variability recording showed a significant decrease in the low-frequency component one month after renal denervation, suggesting it could be a simple, non-invasive predictor of effective sympathetic denervation.
May support HRV as a denervation marker; hypothesis-generating from one case and should not change practice.
The overactivity of sympathetic component of autonomic nervous system is implicated in the genesis and progression of hypertension . We report the heart rate variability (HRV) of a patient after renal denervation for treatment of medically resistant hypertension. Catheter based renal denervation done for treatment of resistant hypertension reduces blood pressure by reducing the central sympathetic drive. In the present study we found a significant decrease in low frequency component of HRV in one month follow-up period after the procedure. We propose a simple, non-invasive 5-minute HRV could be a predictor of effective renal sympathetic denervation.
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Baksh et al. (2013) conducted a case report in Resistant hypertension (n=1). Percutaneous renal denervation vs. Pre-operative baseline was evaluated on Low frequency component of heart rate variability spectrum (0.04-0.15 Hz). Percutaneous renal denervation decreased the low frequency component of heart rate variability from 4.964 to 1.853 and reduced blood pressure by 30/10 mmHg at 1 month in a patient with resistant hypertension.
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