Key result
Oral administration of carboxymethyl-glucan significantly reduced mean arterial pressure (126 vs 171 mmHg) and restored depressed baroreflex sensitivity in conscious renovascular hypertensive rats.
Why the study?
Does carboxymethyl-glucan (CM-G) reduce blood pressure and improve baroreflex sensitivity in renovascular hypertensive rats?
Does carboxymethyl-glucan (CM-G) reduce blood pressure and improve baroreflex sensitivity in renovascular hypertensive rats?
Absolute Event Rate: 126% vs 171%
p-value: p=<0.05
Oral treatment with carboxymethyl-glucan reduces arterial hypertension and restores baroreflex sensitivity via a reduction in sympathetic tone in a rat model of renovascular hypertension.
Requires human trials before any clinical consideration; leaves open translation of glucan effects from renovascular rat models.
This study was designed to investigate the effects of a newly synthesized carboxymethyl-glucan (CM-G) on blood pressure (BP), baroreflex sensitivity (BRS) and sympathetic vascular modulation in renovascular hypertensive rats. Male Wistar rats were divided into four groups: Sham (n = 10); 2K1C (subjected to renal artery clipping to induce renovascular hypertension, n = 10); Sham+CM-G (treated with CM-G, n = 7) and 2K1C+CM-G (treated with CM-G, n=7). The daily treatment with CM-G (40 mg/kg) was performed for 2 weeks. Blood pressure, heart rate (HR), systolic BP variability, baroreflex sensitivity (BRS) and sympathetic vascular tone were evaluated. After six weeks of renal artery clipping, 2K1C rats exhibited arterial hypertension (171 ± 11 vs. 118 ± 4 mmHg, p < 0.05), impaired BRS (-1.30 ± 0.10 vs. -2.59 ± 0.17 bpm.mmHg-1, p < 0.05) and enhanced sympathetic activity as shown by the hexamethonium test (-60 ± 5 vs. -33 ± 2 ΔmmHg, p < 0.05) when compared to sham rats. Oral administration of CM-G in renovascular hypertensive rats reduced hypertension (126 ± 4 vs. 171 ± 11 mmHg, p < 0.05) and improved the BRS (-2.03 ± 0.16 vs. -1.30 ± 0.10 bpm.mmHg-1, p < 0.05) in 2K1C rats when compared to placebo. Those effects seem to be caused by a reduction in sympathetic activity. The present study revealed for the first time that CM-G treatment reduces arterial hypertension and restores arterial baroreflex sensitivity via a reduction in the sympathetic tone in conscious renovascular hypertensive rats.
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Carvalho‐Galvão et al. (2018) studied Renovascular hypertension (n=34). Carboxymethyl-glucan (CM-G) vs. Saline (placebo) was evaluated on Mean arterial pressure (p=<0.05). Oral administration of carboxymethyl-glucan significantly reduced mean arterial pressure (126 vs 171 mmHg) and restored depressed baroreflex sensitivity in conscious renovascular hypertensive rats.
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