Restoration of tubuloglomerular feedback in volume-expanded rats by angiotensin II

View Full Paper

Ask AI

Bookmark

Population

Anesthetized rats with acute extracellular volume expansion

Comparison

Angiotensin II infusion at 16, 48, 54, or 96… vs Volume-expanded state without angiotensin II…

Design

Preclinical

Authors

Discussion

Angiotensin II may regulate TGF in volume expansion; hypothesis-generating in animals and leaves open human relevance.

Population

Anesthetized rats with acute extracellular volume expansion (achieved by infusion of isotonic saline at 9 ml/h)

Intervention

Angiotensin II infusion at 16, 48, 54, or 96 ng.kg-1.min-1

Comparator

Volume-expanded state without angiotensin II infusion

Outcome

Tubuloglomerular feedback (TGF) responses measured by stop-flow pressure (PSF) and single-nephron glomerular filtration rate (SNGFR)surrogate

Angiotensin II restores tubuloglomerular feedback sensitivity in volume-expanded rats, suggesting its role as a physiological regulator of TGF.

Schnermann et al. (1990) studied this question.

View Full Paper

Ask AI

Bookmark