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February 1, 1981HeartOpen Access

Coronary and peripheral arterial responses to ergometrine in patients susceptible to coronary and oesophageal spasm.

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Why the study?

Does ergometrine administration reveal a generalized sensitivity to alpha-adrenergic stimulation in patients susceptible to coronary or oesophageal spasm compared to those without?

Population

Patients subject to coronary artery spasm, oesophageal spasm, or neither.

Comparison

Ergometrine administration vs Comparison among groups

Design

Cross-sectional

Authors

JDJamshed DalalKokilaben Dhirubhai Ambani HospitalADAnthony M. DartPreventive CardiologyHDHuw DaviesJohn Innes Centre

Discussion

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Implication

Ergometrine testing finds no generalized alpha-adrenergic sensitivity in coronary or oesophageal spasm; leaves open distinct mechanisms for targeted study.

Structured PICO

Does ergometrine administration reveal a generalized sensitivity to alpha-adrenergic stimulation in patients susceptible to coronary or oesophageal spasm compared to those without?

P
Population
Patients subject to coronary artery spasm, oesophageal spasm, or neither.
I
Intervention
Ergometrine administration
C
Comparator
Comparison among groups (coronary artery spasm, oesophageal spasm, and neither)
O
Outcome
Degree of diffuse narrowing at different coronary artery sites (not in spasm) and rise in blood pressuresurrogate

Ergometrine testing suggests that coronary and oesophageal spasms are not driven by a generalized sensitivity to alpha-adrenergic stimulation.

Cite This Study

Dalal et al. (1981) studied this question.

synapsesocial.com/papers/6a88585cceefe68dba4fcdc0https://doi.org/10.1136/hrt.45.2.181
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oesophageal spasm and angina : diagnostic value of ergometrine (ergonovine) provocation1980 · 37 citations
  2. 2Circadian variation of exercise capacity in patients with Prinzmetal's variant angina: role of exercise-induced coronary arterial spasm.1979 · 504 citations
  3. 3SERIOUS SIDE EFFECTS OF ERGOMETRINE AND ITS USE IN ROUTINE OBSTETRIC PRACTICE1974 · 38 citations