October 1, 1998Clinical and Experimental Pharmacology and Physiology

Characterization of a Major Slow Oscillation in the Mesenteric Circulation of Conscious Rats

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Population

Conscious, freely moving rats evaluated for mesenteric (n=25) and hindquarter (n=23) blood flows.

Comparison

Pharmacological blockades including acute… vs Baseline spontaneous state.

Design

Preclinical

Follow-up

1 hour periods

Authors

RLRobert LétiennePierre Fabre (France)CJClaude JulienUniversité Claude Bernard Lyon 1 ZZZhiqi ZhangTsinghua University

Discussion

Member takes

Implication

Sympathetic dependence of mesenteric vasomotion in rats; leaves open translation to human splanchnic hemodynamics or disease.

Structured PICO

Population

Conscious, freely moving rats evaluated for mesenteric (n=25) and hindquarter (n=23) blood flows.

Intervention

Pharmacological blockades including acute blockade of autonomic, renin-angiotensin, and vasopressin systems with noradrenaline infusion (n=7), acute inhibition of nitric oxide synthesis with L-NAME (n=8), and chronic guanethidine-sympathectomy (n=12).

Comparator

Baseline spontaneous state.

Outcome

Characteristics of low-frequency (78-269 mHz) oscillations in regional blood flow.surrogate

Mesenteric blood flow in conscious rats exhibits a major slow oscillation that appears to depend on adrenergic vasoconstrictor tone.

Cite This Study

Létienne et al. (1998) studied this question.

synapsesocial.com/papers/6a885a816304c7fd8e4e0146 https://doi.org/10.1111/j.1440-1681.1998.tb02160.x

View Full Paper

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Characterization of a Major Slow Oscillation in the Mesenteric Circulation of Conscious Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of a Major Slow Oscillation in the Mesenteric Circulation of Conscious Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider