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June 1, 1991AJP Heart and Circulatory Physiology

Longitudinal effect of captopril on aortic and arteriolar development in normotensive rats

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Why the study?

Does captopril alter aortic and arteriolar development in normotensive uninephrectomized rats?

Population

Normotensive rats undergoing uninephrectomy

Comparison

Captopril 100 mg/kg/day in drinking water… vs Age-matched controls

Design

Preclinical

Follow-up

8 weeks

Authors

DWD. H. WangEastern Virginia Medical SchoolRPRussell L. PrewittLouisiana State University

Discussion

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Implication

Should not change clinical practice; hypothesis-generating for ACE inhibitor effects on vascular remodeling in normotensive models.

Structured PICO

Does captopril alter aortic and arteriolar development in normotensive uninephrectomized rats?

P
Population
Normotensive rats undergoing uninephrectomy
I
Intervention
Captopril 100 mg/kg/day in drinking water starting 1 day before uninephrectomy
C
Comparator
Age-matched controls
O
Outcome
Medial-intimal area of the abdominal aorta and cremaster arteriolar dimensions at 4 and 8 weekssurrogate

Captopril induces structural changes in the aorta and arterioles, including reduced cross-sectional wall areas and arteriolar rarefaction, in normotensive rats.

Cite This Study

Wang et al. (1991) studied this question.

synapsesocial.com/papers/6a885bae8e586ad1c8a5536chttps://doi.org/10.1152/ajpheart.1991.260.6.h1959
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic captopril administration decreases vasodilator responses in skeletal muscle arterioles1999 · 19 citations
  2. 2Effect of Chronic Treatment with Captopril on Reactivity of Aortic Smooth Muscle from Normotensive and Renal Hypertensive Rats1983 · 10 citations
  3. 3Effect of captopril infusion on systemic and renal haemodynamics in conscious hypertensive rats with chronic, progressive aortic ligation1985 · 3 citations
  4. 4Effects of chronic administration of captopril on blood pressure and the renin-angiotensin-aldosterone system in normotensive rats.1983 · 9 citations
  5. 5Regression of structural vascular changes in hypertensives after captopril treatment1992 · 3 citations