Key result
ST-segment resolution ≥50% after primary PCI was associated with lower 2-year mortality compared to resolution <50% (5.6% vs 11.7%; adjusted HR 0.45; 95% CI 0.36-0.56).
Why the study?
The study evaluated the role of ST-segment resolution alone and combined with TIMI flow for reperfusion evaluation after PPCI for STEMI by investigating their long-term prognostic impact.
Does successful ST-segment resolution alone or combined with TIMI flow predict lower 2-year mortality in patients with STEMI undergoing primary PCI?
Population
5966 STEMI patients enrolled in the CAMI registry with STR evaluated 120 minutes after PPCI
Comparison
STR ≥50% and complete STR vs STR <50%, alone and combined with TIMI flow
Design
Registry-based cohort study
Follow-up
2-year
Authors
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STR may refine post-PCI risk stratification in STEMI; leaves open whether it should guide therapy.
Cohort (n=5,966)
Yes
Does successful ST-segment resolution alone or combined with TIMI flow predict lower 2-year mortality in patients with STEMI undergoing primary PCI?
Hazard Ratio: 0.45 (95% CI 0.36–0.56)
Absolute Event Rate: 5.6% vs 11.7%
Post-PPCI ST-segment resolution is a robust independent predictor of long-term mortality in STEMI patients, and its integration with TIMI flow provides incremental prognostic value.
Wu et al. (2023) conducted a cohort in ST-segment-elevation myocardial infarction (n=5,966). ST-segment resolution (STR) ≥50% vs. STR <50% was evaluated on 2-year all-cause mortality (adjusted HR 0.45, 95% CI 0.36-0.56). ST-segment resolution ≥50% after primary PCI was associated with lower 2-year mortality compared to resolution <50% (5.6% vs 11.7%; adjusted HR 0.45; 95% CI 0.36-0.56).
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