December 14, 1989New England Journal of Medicine

The Relation of Aspirin Use during the First Trimester of Pregnancy to Congenital Cardiac Defects

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Why the study?

Does maternal aspirin use during the first trimester of pregnancy increase the risk of congenital heart defects in infants?

Population

Infants with any structural cardiac defect including aortic stenosis, coarctation of the aorta, hypoplastic…

Comparison

Maternal aspirin use during the first trimester… vs No maternal aspirin use during the first…

Design

Case-control

Authors

MWMartha M. WerlerBoston University AMAllen A. MitchellBoston University SSSamuel ShapiroUniversity of Notre Dame

Discussion

Member takes

Implication

Reassures against increased cardiac defect risk from first-trimester aspirin; leaves open confirmation via prospective studies.

Structured PICO

Does maternal aspirin use during the first trimester of pregnancy increase the risk of congenital heart defects in infants?

Population

Infants with any structural cardiac defect (n=1381) including aortic stenosis (n=43), coarctation of the aorta (n=123), hypoplastic left ventricle (n=98), transposition of the great arteries (n=210), and conotruncal defects (n=791), and a control group of infants with other malformations (n=6966).

Intervention

Maternal aspirin use during the first trimester of pregnancy

Comparator

No maternal aspirin use during the first trimester of pregnancy

Outcome

Congenital heart defects (any structural cardiac defect and specific subtypes)hard clinical

Aspirin use during the first trimester of pregnancy does not appear to increase the risk of congenital heart defects in infants.

Cite This Study

Werler et al. (1989) studied this question.

synapsesocial.com/papers/6a88684ba082a64c2914c98e https://doi.org/10.1056/nejm198912143212404

Topics

Congenital heart disease adults

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The Relation of Aspirin Use during the First Trimester of Pregnancy to Congenital Cardiac Defects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

The Relation of Aspirin Use during the First Trimester of Pregnancy to Congenital Cardiac Defects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider