Why the study?
Does low-molecular-weight heparin reduce acute thrombotic endpoints compared to unfractionated heparin or placebo in a pig model of deep arterial injury?
Population
Pig model of deep arterial injury produced by balloon dilatation of the carotid artery
Comparison
Low-molecular-weight heparin at 100, 200, 400… vs Unfractionated calcium heparin and placebo
Design
Preclinical
Authors
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LMWH reduces mural thrombosis dose-dependently in porcine arterial injury but underperforms UFH at standard doses; leaves open optimal regimens for clinical translation.
Does low-molecular-weight heparin reduce acute thrombotic endpoints compared to unfractionated heparin or placebo in a pig model of deep arterial injury?
In a pig model of deep arterial injury, low-molecular-weight heparin was less effective than unfractionated heparin at reducing platelet thrombus deposition except at high doses.
Heras et al. (1992) studied this question.
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