Why the study?
Does sepsis induced by cecal ligation and perforation alter myocardial collagen content and interstitial space in rats?
Population
Male Sprague-Dawley rats, weighing 310 to 396 g (n=42)
Comparison
Cecal ligation and perforation to induce sepsis… vs Sham laparotomy for 24 hours or 48 hours with…
Design
Preclinical, Randomized
Follow-up
24 or 48 hours
Authors
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May explain sepsis cardiomyopathy via collagen loss in this rat model; hypothesis-generating and requires clinical validation.
Does sepsis induced by cecal ligation and perforation alter myocardial collagen content and interstitial space in rats?
Sepsis is accompanied by decreased myocardial collagen content and increased myocardial edema, which may contribute to sepsis-induced myocardial dysfunction and ventricular dilation.
Yu et al. (1997) studied this question.
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