Population
Single cells isolated from cultured rabbit kidney proximal tubule cells
Comparison
Reduction of extracellular osmolality from 290… vs Baseline osmolality (290 mosmol/kgH2O)
Design
Preclinical
Authors
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Hypotonic swelling activates K channels in rabbit proximal tubules; hypothesis-generating for cell volume regulation with no direct clinical translation.
Hypotonic-induced cell swelling stimulates Ca-activated K channels in rabbit kidney proximal tubule cells, suggesting a role in cell volume regulation.
Kawahara et al. (1991) studied this question.
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