Key result
In rabbit cultured proximal tubule cells, a nifedipine-sensitive, protein kinase C-regulated Ca2+ channel was identified that is activated by PMA and mechanical stretch.
Identifies a nifedipine-sensitive, protein kinase C-regulated and mechanosensitive Ca2+ channel in the apical membranes of rabbit proximal tubule cells.
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No immediate clinical implications in humans; leaves open the channel's role in renal physiology and disease.
Zhang et al. (1996) studied this question. Phorbol 12-myristate 13-acetate (PMA) and mechanical stretch was evaluated on Channel open probability (P0). In rabbit cultured proximal tubule cells, a nifedipine-sensitive, protein kinase C-regulated Ca2+ channel was identified that is activated by PMA and mechanical stretch.
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