Why the study?
Does a single intravenous bolus of labetalol reduce cardiovascular, hyperglycaemic, and adrenocortical responses in patients undergoing major colonic surgery?
Does a single intravenous bolus of labetalol reduce cardiovascular, hyperglycaemic, and adrenocortical responses in patients undergoing major colonic surgery?
A single IV bolus of labetalol blunts the heart rate, rate-pressure product, glucose, and cortisol responses to major colonic surgery.
Labetalol was associated with blunted responses in major colonic surgery; should not yet change practice and leaves open need for RCTs.
The effects of a single intravenous bolus of labetalol (0.5 mg/kg) on the cardiovascular, hyperglycaemic and adrenocortical responses to major colonic surgery were studied in five patients. Results were compared with five patients who received the same anaesthetic and had similar operations performed but who did not receive labetalol. It was observed that labetalol reduced the rises in heart rate and rate-pressure product that occur at the time of skin incision but that it did not reduce the rise in mean arterial pressure. The rises in blood glucose and plasma cortisol were significantly less in the labetalol group after 30 minutes of surgery (p less than 0.05).
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C. S. CHILD (1984) studied this question.
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