PAI-1 appears to be cardioprotective, as its deficiency in aging mice leads to spontaneous cardiac fibrosis.
In this issue of Blood , Xu and colleagues provide evidence that suggests PAI-1 is cardioprotective as demonstrated by the observation that spontaneous cardiac fibrosis occurs in aging PAI-1–deficient (PAI-1−/−) mice, preceded by early changes in cardiac vascular barrier integrity, enhanced
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Miles et al. (2010) studied this question.
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