Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 14, 2001Circulation

Plasminogen Activator Inhibitor-1 Deficiency Prevents Hypertension and Vascular Fibrosis in Response to Long-term Nitric Oxide Synthase Inhibition

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does PAI-1 deficiency prevent hypertension and vascular fibrosis in response to long-term NOS inhibition in male mice?

Population

PAI-1-deficient (PAI-1(-/-)) and wild-type (WT) male mice (N=6 per group)

Comparison

PAI-1 deficiency with long-term nitric oxide… vs Wild-type mice with long-term NOS inhibition by…

Design

Preclinical

Follow-up

8 weeks

Authors

KKKoichi KaikitaAFAgnes B. FogoLMLijun Ma

Discussion

Loading...

Member takes

Overview

PAI-1 deficiency attenuates hypertension in this model; hypothesis-generating for therapeutic targeting and requires human validation before any clinical consideration.

Structured PICO

Does PAI-1 deficiency prevent hypertension and vascular fibrosis in response to long-term NOS inhibition in male mice?

P
Population
PAI-1-deficient (PAI-1(-/-)) and wild-type (WT) male mice (N=6 per group)
I
Intervention
PAI-1 deficiency (genetic knockout) with long-term nitric oxide synthase (NOS) inhibition by N(omega)-nitro-L-arginine methyl ester (L-NAME)
C
Comparator
Wild-type (WT) mice with long-term NOS inhibition by L-NAME
O
Outcome
Temporal changes in systolic blood pressure and coronary perivascular fibrosissurrogate

PAI-1 deficiency protects against structural vascular changes and hypertension induced by long-term NOS inhibition in mice, suggesting vascular PAI-1 as a potential therapeutic target.

Cite This Study

Kaikita et al. (2001) studied this question.

synapsesocial.com/papers/6a8a5088abe412682d9322a8https://doi.org/10.1161/hc3301.092803
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Activation and Inhibition of the Renin-Angiotensin System on Plasma PAI-11998 · 271 citations
  2. 2Angiotensin II Activates Collagen Type I Gene in the Renal Vasculature of Transgenic Mice During Inhibition of Nitric Oxide Synthesis1999 · 88 citations
  3. 3Improved Survival in Rats Administered NG-Nitro L-Arginine Methyl Ester Due to Converting Enzyme Inhibition1996 · 59 citations
  4. 4Chronic Nitric Oxide Inhibition Model Six Years On1998 · 255 citations
  5. 5Protein expression, vascular reactivity and soluble guanylate cyclase activity in mice lacking the endothelial cell nitric oxide synthase: contributions of NOS isoforms to blood pressure and heart rate control1999 · 133 citations