A procedure for the comprehensive screening of blood for basic and neutral drugs is described and evaluated. A rapid n-butyl chloride extraction method is used. Extraction recoveries are determined using megabore capillary and packed column gas chromatography with nitrogen-specific detection. Recoveries and retention times are recorded in tabular form. Detection limits are below 200 nanograms of drug per millilitre of blood.
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M.E. Sharp (1986) studied this question.
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