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July 1, 1988Circulation ResearchOpen Access

Modulation of carotid sinus afferent input to nucleus tractus solitarius by parabrachial nucleus stimulation.

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Population

Cats in which anesthesia was induced with pentobarbital and maintained with alpha-chloralose

Comparison

Electrical stimulation of the parabrachial nucleus vs Unconditioned responses to carotid sinus nerve…

Design

Preclinical

Authors

RFRobert B. FelderUniversity of IowaSMSteven W. MifflinUniversity of the Incarnate Word

Discussion

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Implication

PBN modulates NTS cardiovascular input in rodents; leaves open its role in integrated reflexes and human translation.

Structured PICO

P
Population
Cats in which anesthesia was induced with pentobarbital and maintained with alpha-chloralose
I
Intervention
Electrical stimulation of the parabrachial nucleus (PBN)
C
Comparator
Unconditioned responses to carotid sinus nerve (CSN) stimulation
O
Outcome
Action potential responses and membrane potential changes in nucleus tractus solitarius (NTS) neuronssurrogate

This study demonstrates for the first time that the parabrachial nucleus exerts a potent modulatory influence on nucleus tractus solitarius neurons processing cardiovascular afferent input.

Cite This Study

Felder et al. (1988) studied this question.

synapsesocial.com/papers/6a88eb8a19d633501c130e23https://doi.org/10.1161/01.res.63.1.35
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tyrosine hydroxylase in the rat parabrachial region: ultrastructural localization and extrinsic sources of immunoreactivity1986 · 78 citations
  2. 2Neurotensin in the rat parabrachial region: Ultrastructural localization and extrinsic sources of immunoreactivity1986 · 43 citations