Severe Hypersensitivity to Diphenylhydantoin with Circulating Antibodies to the Drug

Letters1 October 1975Severe Hypersensitivity to Diphenylhydantoin with Circulating Antibodies to the DrugHOWARD B. KLECKNER, M.D., VINCENT YAKULIS, B.S., PAUL HELLER, M.D., F.A.C.P.HOWARD B. KLECKNER, M.D., VINCENT YAKULIS, B.S., PAUL HELLER, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-4-522 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn infrequent adverse reaction to diphenylhydantoin (DPH) is a mononucleosis-like syndrome (1, 2). We report here on such a patient, in whom polyclonal IgG antibodies to DPH were detected.A 15-year-old black high school student was admitted to the University of Illinois Hospital because of fever, skin rash, myalgia, and dark urine. Ten weeks previously he had a convulsive seizure, and diphenylhydantoin, 100 mg three times daily, was prescribed. Seven weeks later a pruritic rash started on his trunk. It gradually spread and was accompanied by fever, myalgia, anorexia, and malaise. On the day of admission his urine turned dark....References1. CHAIKENGOLDBERGSEGAL GGJ: Dilantin sensitivity: report of a case of hepatitis with jaundice, pyrexia and exfoliative dermatitis. N Engl J Med 242:897-898, 1950 CrossrefMedlineGoogle Scholar2. SPARBERG M: Diagnostically confusing complications of diphenylhydantoin therapy. Ann Intern Med 59:914-930, 1963 LinkGoogle Scholar3. LIUADLER CF: Immunologic studies on drug addiction. I. Antibodies reactive with methadone and their detection of the drug. J Immunol 111:472-477, 1973 MedlineGoogle Scholar4. GOLDFUDENBERG EH: Chromic chloride: a coupling reagent for passive hemagglutination reactions. J Immunol 99:859-866, 1967 MedlineGoogle Scholar5. AXENPORATHERNBACK RHS: Chemical coupling of peptides and proteins to polysaccharides by means of cyanogen halides. Nature 214:1302-1304, 1967 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HOWARD B. KLECKNER, M.D.; VINCENT YAKULIS, B.S.; PAUL HELLER, M.D., F.A.C.P.Affiliations: Veterans Administration West Side Hospital Department of Medicine University of Illinois Abraham Lincoln School of Medicine Chicago, Illinois 60612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhenytoin-Associated Granulomatous Pulmonary VasculitisAnticonvulsant AgentsDrug-induced acute liver failure and gastrointestinal complicationsDrug-Induced Respiratory Disease in Connective Tissue DiseasesDrug-Induced HepatotoxicityCorrespondenceArthritis as a rare side effect of phenytoin therapyImmunoreactivity to Various Human Cytochrome P450 Proteins of Sera from Patients with Autoimmune Hepatitis, Chronic Hepatitis B, and Chronic Hepatitis CAcute granulomatous interstitial nephritis and colitis in anticonvulsant hypersensitivity syndrome associated with lamotrigine treatmentImmunvermittelte arzneimittelinduzierte LeberschädenAnticonvulsant Hypersensitivity Syndrome Occurring as Sepsis with Multiorgan DysfunctionPhenytoin-Induced Dermatomyositis: Case Report and Literature ReviewANTICONVULSANT HYPERSENSITIVITY SYNDROMEXenobiotic-induced hepatotoxicity: mechanisms of liver injury and methods of monitoring hepatic functionPediatric Hepatic Drug ReactionsAntiepileptic DrugsDetermining the true cause of death in a dermatological disasterHEPATOTOXICITY OF ANESTHETICS AND OTHER CENTRAL NERVOUS SYSTEM DRUGSDrug-Induced HepatotoxicityDrug-induced hepatotoxicityAdverse Effects of Drugs on the LiverPhenytoin Hypersensitivity Syndrome: A Case ReportThe role of N-oxidation by leukocytes in drug-induced agranulocytosis and other drug hypersensitivity reactionsAcne Keloidalis-like Lesions on the Scalp Associated with Antiepileptic DrugsAllergic reactions to drugs: current concepts and problemsPhenytoin Hepatotoxicity: A Review of the LiteratureCutaneous and immunologic reactions to phenytoinPhenytoin syndrome developing after administration of dilantin for an enflurane-induced seizureIdiosyncratic Reactions to PhenytoinPhenytoin hypersensitivity syndromeOutpatient Drug-Induced Parenchymal Liver Disease Requiring HospitalizationPhenytoin hypersensitivity: A case of severe acute rhabdomyolysisA Comparative Study of Laboratory Parameters in Head-Injured Patients Receiving Either Phenytoin or Placebo for 24 MonthsAdverse EffectsA common pathway for chemical-induced tissue injury and immune responses leading to hypersensitivity and/or carcinogenesisPhenytoin hypersensitivity reaction presenting with toxic epidermal necrolysis and severe hepatitisImmunologic aspects of phenobarbital hypersensitivitySide effects of phenobarbital and phenytoin during long-term treatment of epilepsyHepatic toxicity of antiepileptic drugs: A reviewDilantin digital defectsAntigranulocyte antibodies and deranged immune function associated with phenytoin-induced serum sicknessThe mucocutaneous lymph node syndrome: a critical re-examinationPhenytoin Hypersensitivity Reaction: Hepatic necrosisDrag-related Acute and Chronic Hepatitis 1 October 1975Volume 83, Issue 4Page: 522-523KeywordsAdverse reactionsAntibodiesEpileptic seizuresFeversHypersensitivityMyalgiaRashesUrine ePublished: 1 December 2008 Issue Published: 1 October 1975 PDF downloadLoading ...