Population
Isolated superior mesenteric arteries from spontaneously hypertensive rats and normotensive Wistar-Kyoto rats
Comparison
Acetylcholine with or without various receptor… vs WKY rats (normotensive controls) vs SHRs
Design
Preclinical
Authors
Loading...
Hypothesis-generating for EDHF-M3 pathway in hypertensive endothelial dysfunction; leaves open translation to human vessels or therapies.
The impairment of acetylcholine-induced vasorelaxation in spontaneously hypertensive rats is primarily mediated by a reduction in endothelium-derived hyperpolarizing factor (EDHF) activity via M3-receptor activation.
Wu et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: