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January 1, 1999Scandinavian Journal of Clinical and Laboratory Investigation

Impaired endothelium-dependent relaxation in mesenteric arteries of reduced renal mass hypertensive rats

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Population

Male Wistar rats with reduced renal mass hypertension induced by subtotal nephrectomy and salt-loading

Comparison

Acetylcholine to induce endothelium-dependent… vs Control group of male Wistar rats that drank tap…

Design

Preclinical

Follow-up

2 weeks

Authors

KKKeizo KimuraINIchiro Nishio

Discussion

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Overview

Hypothesis-generating for endothelial dysfunction in volume-dependent hypertension; leaves open human translation.

Structured PICO

P
Population
Male Wistar rats with reduced renal mass hypertension induced by subtotal nephrectomy and salt-loading
I
Intervention
Acetylcholine (ACh) to induce endothelium-dependent relaxation in isolated superior mesenteric arterial rings
C
Comparator
Control group of male Wistar rats that drank tap water after subtotal nephrectomy
O
Outcome
Endothelium-dependent relaxation mediated by endothelium-derived nitric oxide (EDNO) and hyperpolarizing factor (EDHF)surrogate

In a rat model of volume-dependent hypertension, endothelium-dependent relaxation mediated by both EDNO and EDHF is depressed due to an arterial endothelial abnormality.

Cite This Study

Kimura et al. (1999) studied this question.

synapsesocial.com/papers/6a127cf7c031bb6829a6b5aehttps://doi.org/10.1080/00365519950185724
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Also Consider

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