Effects Of Digoxin, Furosemide, Enalaprilat And Metoprolol On Endothelial Function In Young Normotensive Subjects
Why the study?
Do intra-arterial infusions of digoxin, furosemide, enalaprilat, or metoprolol improve endothelium-dependent vasodilation in young healthy normotensive subjects?
Population
37 young healthy normotensive subjects
Comparison
1 hour intra-arterial infusion of digoxin… vs 1 hour intra-arterial infusion of saline
Follow-up
1 hour
Authors
Discussion
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Member takes
Implication
Acute enalaprilat and digoxin effects on endothelial function in healthy volunteers should not change practice; hypothesis-generating for broader populations.
Structured PICO
Do intra-arterial infusions of digoxin, furosemide, enalaprilat, or metoprolol improve endothelium-dependent vasodilation in young healthy normotensive subjects?
P
Population
37 young healthy normotensive subjects
I
Intervention
1 hour intra-arterial infusion of digoxin (0.1 mg/h), furosemide (5.0 mg/h), enalaprilat (2.4 mg/h), or metoprolol (1.2 mg/h)
C
Comparator
1 hour intra-arterial infusion of saline (controls)
O
Outcome
Endothelium-dependent vasodilation (EDV) evaluated by forearm blood flow (FBF) response to methacholine (MCh)surrogate
Enalaprilat and furosemide improve endothelial vasodilatory function in young normotensive subjects, suggesting direct endothelial effects of these commonly used cardiovascular drugs.
Cite This Study
Mühlen et al. (2001) studied this question.