June 1, 1998Clinical Science
Acute Hypertension Impairs Endothelium-Dependent Vasodilatation
Why the study?
Does an acute rise in blood pressure to hypertensive levels impair endothelium-dependent vasodilatation in healthy normotensive subjects?
Population
27 young, healthy, normotensive subjects
Comparison
1 hour of sustained hypertension induced by… vs Baseline measurements, local intra-arterial…
Follow-up
1 hour
Authors
Discussion
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Member takes
Implication
Acute BP rises may impair endothelial function; leaves open its contribution to hypertension pathogenesis and requires larger validation before clinical consideration.
Structured PICO
Does an acute rise in blood pressure to hypertensive levels impair endothelium-dependent vasodilatation in healthy normotensive subjects?
P
Population
27 young, healthy, normotensive subjects
I
Intervention
1 hour of sustained hypertension (diastolic blood pressure > 95 mmHg) induced by intravenous noradrenaline
C
Comparator
Baseline measurements, local intra-arterial noradrenaline without blood pressure change, and saline infusions
O
Outcome
Endothelium-dependent vasodilatation (EDV) and endothelium-independent vasodilatation (EIDV) assessed by forearm blood flow and vascular resistance during local intra-arterial infusions of methacholine and sodium nitroprussidesurrogate
An acute rise in blood pressure to hypertensive levels selectively impairs endothelium-dependent vasodilatation, suggesting that high blood pressure directly causes endothelial dysfunction.
Cite This Study
Millgård et al. (1998) studied this question.