December 1, 1996Journal of Hypertension

Insulin sensitivity following treatment with the ??1-blocker bunazosin retard and the ??1-blocker atenolol in hypertensive non-insulin-dependent diabetes mellitus patients

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Why the study?

Does bunazosin retard improve insulin sensitivity compared to atenolol in patients with type-2 diabetes and hypertension?

Structured PICO

Does bunazosin retard improve insulin sensitivity compared to atenolol in patients with type-2 diabetes and hypertension?

Population

47 patients with controlled type-2 diabetes (treated by diet or oral sulphonylurea) and mild-to-moderate hypertension (seated diastolic blood pressure 90-114 mmHg).

Intervention

Bunazosin retard 3, 6, or 12 mg orally once a day for 16 weeks (dose titrated to blood pressure response)

Comparator

Atenolol 25, 50, or 100 mg orally once a day for 16 weeks (dose titrated to blood pressure response)

Outcome

Insulin sensitivity assessed as glucose utilization during euglycaemic hyper-insulinaemic clamp after 16 weeks of treatmentsurrogate

In patients with type-2 diabetes and hypertension, treatment with the alpha-1 blocker bunazosin retard is associated with better preserved insulin sensitivity compared to the beta-1 blocker atenolol.

Discussion

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Implication

Supports alpha-1 over beta-blockade when preserving insulin sensitivity matters in diabetic hypertension; extends class-specific metabolic comparisons.

Cite This Study

Eriksson et al. (1996) studied this question.

synapsesocial.com/papers/6a88f2b1c80974a9031a1e40 https://doi.org/10.1097/00004872-199612000-00014

Topics

Hypertension management

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Implication

Supports alpha-1 over beta-blockade when preserving insulin sensitivity matters in diabetic hypertension; extends class-specific metabolic comparisons.

Insulin sensitivity following treatment with the ??1-blocker bunazosin retard and the ??1-blocker atenolol in hypertensive non-insulin-dependent diabetes mellitus patients

Structured PICO

Discussion

Implication

Cite This Study

Topics

Insulin sensitivity following treatment with the ??1-blocker bunazosin retard and the ??1-blocker atenolol in hypertensive non-insulin-dependent diabetes mellitus patients

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider