Why the study?
Does multiple-dose propranolol alter the single-dose pharmacokinetics of quinapril and quinaprilat in healthy volunteers?
Does multiple-dose propranolol alter the single-dose pharmacokinetics of quinapril and quinaprilat in healthy volunteers?
Co-administration of multiple-dose propranolol does not affect the pharmacokinetics of a single dose of quinapril or its active metabolite.
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May support co-administration without dose adjustment in volunteers; leaves open effects in patients or with chronic regimens.
Horvath et al. (1990) studied this question.
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