Population
Rat portal vein smooth muscle preparations
Comparison
Respiratory inhibition by 0.2 mM cyanide vs Control (no cyanide)
Design
Preclinical
Authors
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No immediate clinical implications; leaves open metabolic regulation of vascular contractility in human disease models.
Inhibition of cellular respiration in rat portal vein smooth muscle reduces force and shortening velocity, likely due to decreased myosin light chain phosphorylation rather than altered calcium sensitivity.
Ekmehag et al. (1989) studied this question.
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