September 1, 1985Circulation Research

Phorbol ester- and diacylglycerol-mediated desensitization of cardiac beta-adrenergic receptors.

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Population

Enzymatically dissociated rat cardiac myocytes

Design

Preclinical

Authors

CLC LimasUniversity of Minnesota CLC LimasUniversity of Minnesota

Discussion

Member takes

Implication

May implicate PKC in cardiac β-receptor desensitization; hypothesis-generating with relevance to human HF untested.

Structured PICO

Population

Enzymatically dissociated rat cardiac myocytes

Intervention

Incubation with biologically active phorbol esters (4 beta-phorbol-12, 13-dibutyrate and 12-O-tetradecanoyl phorbol-13-acetate) or synthetic diacylglycerol (1-oleyl-2-acetyldiglycerol)

Outcome

Loss of beta-adrenergic receptors (desensitization) detectable with [3H]-CGP-12177surrogate

Protein kinase C activation by diacylglycerols derived from receptor-linked phosphoinositide hydrolysis may be a novel mechanism of cardiac beta-receptor desensitization.

Cite This Study

Limas et al. (1985) studied this question.

synapsesocial.com/papers/6a8908f4353a6a8ef2a5edd4 https://doi.org/10.1161/01.res.57.3.443

View Full Paper

Ask AI

Bookmark

Phorbol ester- and diacylglycerol-mediated desensitization of cardiac beta-adrenergic receptors.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Phorbol ester- and diacylglycerol-mediated desensitization of cardiac beta-adrenergic receptors.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider