June 10, 1996FEBS Letters

Porcine polypyrimidine tract‐binding protein stimulates translation initiation at the internal ribosome entry site of foot‐and‐mouth‐disease virus

View Full Paper

Ask AI

Bookmark

Population

Rabbit reticulocyte lysate translation system from which the internal PTB had been depleted

Design

Preclinical

Authors

Discussion

sPTB functionally substitutes for human PTB in FMDV IRES assays; leaves open in vivo or cellular relevance.

Population

Rabbit reticulocyte lysate translation system from which the internal PTB had been depleted

Intervention

Purified recombinant porcine polypyrimidine tract-binding protein (sPTB)

Outcome

Stimulation of internal translation initiation directed by the foot-and-mouth-disease virus (FMDV) internal ribosome entry site (IRES)

Porcine PTB is highly homologous to human PTB and can efficiently stimulate translation initiation at the FMDV IRES.

Michael Niepmann (1996) studied this question.

View Full Paper

Ask AI

Bookmark