What does this research mean for the field?

Q: What does this research mean for the field?

A cellular 57-kDa protein (p57) specifically binds to two distinct sites sharing a UUUC motif within the internal translation initiation site of foot-and-mouth disease virus RNA and other picornaviruses. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1991Journal of VirologyOpen Access

Interaction of a cellular 57-kilodalton protein with the internal translation initiation site of foot-and-mouth disease virus

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Population

Cell extracts of different mammalian species

Design

Preclinical

Authors

NLNÁYRA RACHEL NASCIMENTO LUZPepsiCo (United Kingdom)EBEwald BeckGiessen School of Theology

Discussion

Member takes

Implication

p57-FMDV interaction may guide antiviral targeting of viral translation; hypothesis-generating and requires in vivo validation before any application.

Structured PICO

Population

Cell extracts of different mammalian species

Intervention

UV cross-linking and footprint analyses

Outcome

Binding of a cellular 57-kDa protein (p57) to the internal translation initiation site in the 5' untranslated region of foot-and-mouth disease virus RNAsurrogate

Identifies a 57-kDa cellular protein that binds to the internal translation initiation site of foot-and-mouth disease virus RNA, suggesting its role in viral translation.

Cite This Study

LUZ et al. (1991) studied this question.

synapsesocial.com/papers/6a18b577d654b1eb0d4ace1f https://doi.org/10.1128/jvi.65.12.6486-6494.1991

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Implication

p57-FMDV interaction may guide antiviral targeting of viral translation; hypothesis-generating and requires in vivo validation before any application.

Interaction of a cellular 57-kilodalton protein with the internal translation initiation site of foot-and-mouth disease virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Interaction of a cellular 57-kilodalton protein with the internal translation initiation site of foot-and-mouth disease virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider