Answers are grounded in this paper and cite their sources.
Identified two specific binding sites for a 57 kDa host protein on the internal ribosomal entry site of foot-and-mouth disease virus RNA.
A ribosome-associated 57 kDa protein from rabbit reticulocytes was linked to the internal translation initiation site of foot-and-mouth disease virus by mild UV-irradiation. Binding studies with different RNA fragments revealed that this protein interacts with two distinct sites within the translational control region. One site is located approximately 400 nucleotides upstream from the translational start codon and the second binding site could be confined to 60 nucleotides preceding this codon. Both sequences coincide with hairpin structures at the two opposite ends of a secondary structure model of the internal ribosomal entry site proposed by Pilipenko et al. [(1989) Nucleic Acids Res. 17, 5701-5711].
No takes yet. Share an insight, caveat, or question.
LUZ et al. (1990) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: