Why the study?
Does tempol and/or ET(B) receptor blockade alter mean arterial pressure in male Sprague-Dawley rats on a high-salt diet?
Population
Male Sprague-Dawley rats fed a normal- or high-salt diet
Comparison
Tempol, A-192621, or both vs Control group
Design
Preclinical
Follow-up
1 week
Authors
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Tempol lowers MAP selectively in high-salt rats; leaves open mechanisms and human translation for salt-sensitive hypertension.
Does tempol and/or ET(B) receptor blockade alter mean arterial pressure in male Sprague-Dawley rats on a high-salt diet?
In rats on a high-salt diet, tempol lowers blood pressure, an effect that may be unrelated to reductions in superoxide, while renal H2O2 may limit its ability to attenuate hypertension produced by ET(B) receptor blockade.
Williams et al. (2004) studied this question.
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