April 15, 2009The Journal of RheumatologyOpen Access

Peripheral Arterial Stiffness and Endothelial Dysfunction in Idiopathic and Scleroderma Associated Pulmonary Arterial Hypertension

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Population

59 subjects total: 38 patients with idiopathic and scleroderma-associated pulmonary arterial hypertension…

Design

Cross-sectional

Authors

NPNir PeledShaare Zedek Medical Center DSDavid ShitritTel Aviv University BFBenjamin D. FoxTel Aviv University

Discussion

Member takes

Implication

May indicate systemic vascular involvement in PAH; leaves open prognostic or therapeutic implications.

Structured PICO

Population

59 subjects total: 38 patients with idiopathic (n=28) and scleroderma-associated (n=10) pulmonary arterial hypertension (PAH), and 21 control subjects (13 healthy; 8 with scleroderma and normal pulmonary pressure).

Comparator

Healthy controls and scleroderma patients with normal pulmonary pressure

Outcome

Peripheral arterial stiffness (augmentation index, AI) and endothelial function (peripheral arterial tone, PAT ratio)surrogate

Patients with idiopathic and scleroderma-associated PAH exhibit peripheral endothelial dysfunction, suggesting systemic vascular involvement beyond the pulmonary circulation.

Cite This Study

Peled et al. (2009) studied this question.

synapsesocial.com/papers/6a89164da91e1af1c01a18aa https://doi.org/10.3899/jrheum.081088

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Peripheral Arterial Stiffness and Endothelial Dysfunction in Idiopathic and Scleroderma Associated Pulmonary Arterial Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Peripheral Arterial Stiffness and Endothelial Dysfunction in Idiopathic and Scleroderma Associated Pulmonary Arterial Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider