March 1, 1998Endocrinology

Isolation and Characterization of the 5'-Flanking Regulatory Region of the Human Natriuretic Peptide Receptor C Gene

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Population

Human cells highly producing NPR-C transcripts and genomic clones containing over 8 kilobases of the…

Design

Preclinical

Authors

NYN. Yanaka

Discussion

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Implication

No immediate clinical implications from this animal model; leaves open NPR-C enhancer roles in human atherosclerosis.

Structured PICO

Population

Human cells highly producing NPR-C transcripts and genomic clones containing over 8 kilobases of the 5′-flanking region of the human NPR-C gene

Intervention

Promoter analysis using deletion constructs

Outcome

Promoter activity and identification of regulatory elementssurrogate

This study characterizes the 5'-regulatory region of the human NPR-C gene, identifying key cis-acting sequences that regulate its expression, which may be relevant to vascular smooth muscle cell modulation in atherosclerosis.

Cite This Study

N. Yanaka (1998) studied this question.

synapsesocial.com/papers/6a8916e46abbd4965f28b24b https://doi.org/10.1210/en.139.3.1389

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Isolation and Characterization of the 5'-Flanking Regulatory Region of the Human Natriuretic Peptide Receptor C Gene

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Isolation and Characterization of the 5'-Flanking Regulatory Region of the Human Natriuretic Peptide Receptor C Gene

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider