Why the study?
Is the C(-55) variant of the NPRC P1 promoter associated with altered ANP levels and blood pressure in obese hypertensive patients?
Population
232 white Caucasians, including a subset of 84 patients with essential hypertension.
Comparison
Presence of the C variant in the NPRC P1 promoter vs AC genotype
Design
Cross-sectional
Authors
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C(-55) NPRC variant links to lower ANP and higher SBP in obese hypertension; hypothesis-generating, requires prospective validation.
Is the C(-55) variant of the NPRC P1 promoter associated with altered ANP levels and blood pressure in obese hypertensive patients?
The C(-55) variant of the NPRC P1 promoter is associated with lower ANP levels and higher blood pressure in obese hypertensive patients, suggesting a genetic mechanism for obesity-related hypertension.
Sarzani et al. (1999) studied this question.
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