Key result
Family history of hypertension linked to ~79% higher frequency of the novel Npr1 3C allele.
Why the study?
Are allelic variants of natriuretic peptide receptor genes (Npr1 and Npr3) associated with a family history of hypertension and altered cardiovascular phenotypes in young normotensive subjects?
Population
97 young normotensive subjects, including 45 with an accurately assessed family history of hypertension and…
Comparison
Presence of allelic variants of Npr1 and Npr3… vs Absence of the specific allelic variants or…
Design
Case-control
Authors
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Supports genetic contribution to familial hypertension; leaves open clinical utility of Npr1 testing in young normotensives.
Case-Control (n=97)
Are allelic variants of natriuretic peptide receptor genes (Npr1 and Npr3) associated with a family history of hypertension and altered cardiovascular phenotypes in young normotensive subjects?
Absolute Event Rate: 59% vs 33%
p-value: p=<0.001
A novel functional variant in the Npr1 gene is associated with a family history of hypertension, higher systolic blood pressure, and prolonged ventricular relaxation in young normotensive individuals, suggesting a genetic basis for early cardiovascular changes.
Pitzalis et al. (2003) conducted a case-control in Family history of hypertension (n=97). Family history of hypertension vs. No family history of hypertension was evaluated on Frequency of the novel Npr1 3C allele (p=<0.001). A family history of hypertension was associated with a significantly higher frequency of the novel Npr1 3C allele compared to no family history (59% vs 33%, P<0.001).
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