January 1, 1993American Journal of Hypertension

Family History Studies in Hypertension Research Review of the Literature

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Why the study?

Does a family history of hypertension correlate with early pathophysiologic changes in normotensive individuals?

Population

Normotensive individuals with and without a family history of hypertension (review of >150 studies)

Comparison

Positive family history of hypertension vs No family history of hypertension

Design

Review

Authors

MMMatthew F. MuldoonPreventive Cardiology DTDebra F. TerrellJohnson C. Smith University CBClareann H. BunkerUniversity College London Hospitals NHS Foundation Trust

Discussion

Member takes

Implication

Normotensive individuals with a family history of hypertension exhibit early cardiac morphologic and vascular changes, suggesting pathophysiologic alterations predate clinical hypertension.

Structured PICO

Does a family history of hypertension correlate with early pathophysiologic changes in normotensive individuals?

Population

Normotensive individuals with and without a family history of hypertension (review of >150 studies)

Intervention

Positive family history of hypertension

Comparator

No family history of hypertension

Outcome

Pathophysiologic factors predating the development of high blood pressure (including cellular salt transport, cardiovascular morphology, and reactivity)surrogate

Normotensive individuals with a family history of hypertension exhibit early cardiac morphologic and vascular changes, suggesting pathophysiologic alterations predate clinical hypertension.

Limitations

Inconsistent results across studies
Heterogeneity of essential hypertension
Methodological weaknesses such as failure to confirm blood pressure status of family members
Use of weak study designs (e.g., defining positive history by a single hypertensive first-degree relative)

Cite This Study

Muldoon et al. (1993) studied this question.

synapsesocial.com/papers/6a71a6eab5c1fe5ca9dfe041 https://doi.org/10.1093/ajh/6.1.76

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Implication

Normotensive individuals with a family history of hypertension exhibit early cardiac morphologic and vascular changes, suggesting pathophysiologic alterations predate clinical hypertension.

Family History Studies in Hypertension Research Review of the Literature

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Family History Studies in Hypertension Research Review of the Literature

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider