Key result
The A(-55)A NPRC genotype was associated with a significantly lower prevalence and 20-year rate of overweight, obesity, and abdominal adiposity compared with CC+CA genotypes in adult men.
Why the study?
Does the NPRC gene polymorphism C(-55)A associate with blood pressure, overweight/obesity, and body fat distribution in adult males?
Population
787 untreated male participants from the Olivetti Heart Study in Naples
Comparison
NPRC gene polymorphism C(-55)A (AA genotype) vs CC+CA genotypes
Design
Cohort
Follow-up
20 years for a subgroup of 356 participants
Authors
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A(-55)A NPRC genotype linked to lower obesity risk in men; leaves open causal effects on cardiometabolic outcomes and need for replication.
Observational (n=787)
No
Does the NPRC gene polymorphism C(-55)A associate with blood pressure, overweight/obesity, and body fat distribution in adult males?
The A(-55)A NPRC genotype is associated with a lower prevalence and incidence of overweight and abdominal adiposity in adult men, supporting the lipolytic role of natriuretic peptides.
Sarzani et al. (2004) conducted an observational in Overweight, obesity, and abdominal adiposity (n=787). A(-55)A NPRC genotype vs. CC+CA NPRC genotypes was evaluated on Blood pressure, BMI, waist circumference, and prevalence of overweight/obesity. The A(-55)A NPRC genotype was associated with a significantly lower prevalence and 20-year rate of overweight, obesity, and abdominal adiposity compared with CC+CA genotypes in adult men.
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