March 1, 1998EndocrinologyOpen Access

Isolation and Characterization of the 5′-Flanking Regulatory Region of the Human Natriuretic Peptide Receptor C Gene1

View Full Paper

Ask AI

Bookmark

Population

Human cells highly producing NPR-C transcripts and a genomic clone containing over 8 kilobases of the…

Design

Preclinical

Authors

NYNoriyuki YanakaHiroshima University JKJun KoteraMitsubishi Tanabe Pharma Corporation KOKenji OmoriTarget (United States)

Discussion

Member takes

Implication

These promoter insights are hypothesis-generating for VSMC modulation; human validation required before any clinical consideration.

Structured PICO

Population

Human cells highly producing NPR-C transcripts and a genomic clone containing over 8 kilobases of the 5'-flanking region of the human NPR-C gene

Intervention

Promoter analysis using deletion constructs, primer extension, ribonuclease protection analyses, and deoxyribonuclease I footprinting

Outcome

Identification of essential DNA sequences and molecular mechanisms in NPR-C gene expression, including promoter activity and enhancer functionsurrogate

This study identifies the structure and multiple cis-acting positive sequences of the 5'-regulatory region of the human NPR-C gene, which plays a role in vascular smooth muscle cell phenotypic modulation.

Cite This Study

Yanaka et al. (1998) studied this question.

synapsesocial.com/papers/6a8916e46abbd4965f28b24c https://doi.org/10.1210/endo.139.3.5781

View Full Paper

Ask AI

Bookmark

Isolation and Characterization of the 5′-Flanking Regulatory Region of the Human Natriuretic Peptide Receptor C Gene1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Isolation and Characterization of the 5′-Flanking Regulatory Region of the Human Natriuretic Peptide Receptor C Gene1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider