Why the study?
Does isoflurane reduce myocardial contractility in isolated cat papillary muscles from normal and failing hearts?
Does isoflurane reduce myocardial contractility in isolated cat papillary muscles from normal and failing hearts?
Isoflurane exerts a more pronounced negative inotropic effect on failing hearts compared to normal hearts in an isolated cat papillary muscle model.
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Isoflurane may depress contractility more in failing myocardium; leaves open clinical relevance in perioperative heart failure management.
The inotropic effect of isoflurane (Forane) was studied in papillary muscles from cats with normal hearts (NH) and those with experimentally produced congestive heart failure (CHF). Mean maximal velocity of shortening (Vmax) and mean maximal developed force (Fm) of CHF muscles were lower than in the normal heart. Isoflurane at the concentration equivalent to MAC in man reduced Vmax an average of 36 per cent in NH and 51 per cent in CHF muscles. Average percentage decreases in Fm were 40 in NH and 52 in CHF muscles. When changes in myocardial contractility of CHF muscles exposed to isoflurane at MAC were compared with the NH control values, reductions of Vmax and Fm were 75 and 74 per cent, respectively. The combined negative inotropic effects of isoflurane and CHF were more pronounced than that of isoflurane alone on the normal heart.
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Kemmotsu et al. (1973) studied this question.
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