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February 1, 1996Journal of General Virology

Identification of hepatitis A virus non-structural protein 2B and its release by the major virus protease 3C

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Population

Recombinant animal cells (BT7-H) and HAV-infected MRC-5 cells

Design

Preclinical

Authors

RGRainer GosertUniversity Hospital of BaselPCP. CassinottiCell Medica (Switzerland)GSG. SieglUniversity of North Carolina at Chapel Hill

Discussion

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Implication

No immediate clinical impact; extends HAV polyprotein processing maps for future antiviral research.

Structured PICO

P
Population
Recombinant animal cells (BT7-H) and HAV-infected MRC-5 cells
I
Intervention
Expression of HAV using a vaccinia virus recombinant (vRGORF) containing the complete HAV ORF under the control of the bacteriophage T7 promoter
O
Outcome
Identification of non-structural protein 2B and its cleavage sitesurrogate

The study identifies the hepatitis A virus non-structural protein 2B and demonstrates that its release from the polyprotein is mediated by the viral protease 3C.

Cite This Study

Gosert et al. (1996) studied this question.

synapsesocial.com/papers/6a891e0958d99da5144d34d3https://doi.org/10.1099/0022-1317-77-2-247
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stability of Hepatitis A Virus1984 · 170 citations
  2. 2Expression and characterization of recombinant hepatitis A virus 3C proteinase1992 · 61 citations
  3. 3Structure of the hepatitis A virion: peptide mapping of the capsid region1986 · 54 citations
  4. 4Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses1987 · 385 citations
  5. 5Antigenic and genetic variation in cytopathic hepatitis A virus variants arising during persistent infection: evidence for genetic recombination1991 · 211 citations