This is the first reported case of Abiotrophia defectiva infective endocarditis leading to ANCA-associated glomerulonephritis, demonstrating successful management with antibiotics and dual valve replacement.
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Reports successful antibiotics plus dual valve replacement for rare A. defectiva IE with ANCA GN; leaves open broader applicability and causality.
Abiotrophia defectiva, a nutritionally deficient streptococcus, is a rare cause of infective endocarditis. It has been associated with hemophagocytic syndrome. We present the first case of A. defectiva infective endocarditis that led to antineutrophil cytoplasmic antibody-associated glomerulonephritis. The patient was a 55-year-old man whose endocarditis affected the mitral and aortic valves. His course was complicated by atrial fibrillation, stroke, and glomerulonephritis. He was successfully treated with antibiotics and dual valve replacement.
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Elashery et al. (2020) studied this question.
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